Induction of Maxillary and Mandibular Squamous Epithelial Cell Proliferation in Mink (Neovison vison) by b-Naphthoflavone

Danielle K. Matz, Joanna Chuck, Robin J. Hosmer, Hannah C. Piper, Jane E. Link, Scott D. Fitzgerald, Juan P. Steibel, Steven J. Bursian: Department of Biochemistry and Molecular Biology, Department of Animal Science, Department of Pathobiology and Diagnostic Investigation, Veterinary Diagnostic Laboratory, Institute for Integrative Toxicology Michigan State University, East Lansing Michigan, USA .

Abstract: A jaw lesion reported in mink exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and TCDD-like chemicals is considered a potential indicator of exposure to these chemicals. Many of the effects of TCDD-like chemicals are induced through interaction with the aryl hydrocarbon receptor. The present study indicates that mink dosed with b-naphthoflavone, which is an aryl hydrocarbon receptor ligand but not a TCDD-like chemical, also develop the lesion.

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